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Dopamine modulates acute response to cocaine, nicotine and ethanol in Drosophila

Dopamine modulates acute responses to cocaine, nicotine and ethanol in Drosophila

In this paper researchers study the role of dopamine in different drug exposures. To test how flies responded to cocaine and nicotine they tested how quickly they could climb up a glass tube. With the effects of the drug, flies would remain at the bottom of the tube. Cocaine recovery time was fifteen minutes for moderate doses and nicotine was five minutes for moderate doses. To test the effects of Dopamine, researchers used Dopamine depleted flies by feeding them a competitive antagonist to tyrosine hydroxylase which in necessary for dopamine synthesis. A complete lack of Dopamine results in lethality, so flies tested only have significantly reduced dopamine in their systems. When these flies were tested with cocaine or nicotine they shows a 35% reduction in ability to geotax (climb). These factors are contributed to dopamine reductions, due to a normalized response when the dopamine reduction was reversed. Similar effects happen when testing ethanol instead of cocaine or nicotine.