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Multi-tissue DNA methylation age predictor in mouse

Thomas M. Stubbs et al.


DOI: 

10.1186/s13059-017-1203-5

Generation of a comprehensive genome methylation map of a variety of tissue samples in mice aids in the analysis of epigenetic methylation effects on aging. Samples were obtained from newborn mice up to the age of 41 weeks. The collection of 329 genomic sites allowed the formation of an epigenetic ageing clock that effectively predicts life span and does so more accurately than recently formulated human epigenetic clocks.
And not only does the clock predict chronological age, but biological age as well. The methylome is available for use in ageing research with the potential for reversal of ageing patterns via manipulation of methylation sites.